SUSTALIV [Glucosamine sulfate + Meloxicam] 1500 +15 mg Granules for oral solution
Instructions
for the medical use of the medicinal product
SUSTALIV
Tradename
Sustaliv, Сусталив
International
non-proprietary name or generic name
Glucosamine + Meloxicam, Глюкозамин + Мелоксикам Composition
Each sachet contains:
active
substances: glucosamine sulfate 1500 mg, meloxicam 15 mg;
excipients: colloidal silicon dioxide, sodium lauryl
sulfate, PEG 4000, sodium saccharin, anhydrous citric acid, sorbitol 70.0%, PVP
K 30, aspartame, lemon flavor, sugar.
Dosage form
Granules for oral solution. Pharmacotherapeutic
group Tissue regeneration stimulant
Non-steroidal anti-inflammatory drug (NSAID)
Pharmacological
properties
Glucosamine
is the main building material for connective tissue.
Anti-inflammatory agent, compensates for the endogenous deficiency of
glucosamine, increases the permeability of the joint capsule, restores
enzymatic processes in the cells of the synovial membrane and articular
cartilage. Promotes the fixation of sulfur in the process of synthesis of
chondroitinsulfuric acid, facilitates the normal deposition of calcium in bone
tissue, inhibits the development of degenerative processes in the joints,
restores their function, reducing joint pain.
Meloxicam
is a non-steroidal anti-inflammatory drug with analgesic, anti-inflammatory and antipyretic effects.
Inhibits the synthesis of prostaglandins as a result of selective suppression
of the enzymatic activity of cyclooxygenase-2 (COX-2), which is involved in the
biosynthesis of prostaglandins in the area of inflammation. When used in high
doses, long-term use and individual characteristics of the organism, COX-2
selectivity decreases. Suppresses the synthesis of prostaglandins in the area
of inflammation to a greater extent than in the gastric mucosa or kidneys, which
is associated with a relatively selective inhibition of COX-2. Rarely causes
erosive and ulcerative changes in the gastrointestinal tract. To a lesser
extent, meloxicam acts on cyclooxygenase-1 (COX-1), which is involved in the
synthesis of prostaglandins that protect the mucous membrane of the
gastrointestinal tract (GIT) and are involved in the regulation of blood flow in
the kidneys.
Indications for
use
Osteoarthritis of the peripheral
joints and spine, osteochondrosis, rheumatoid arthritis, ankylosing spondylitis
(Bekhterev's disease), degenerative joint diseases accompanied by pain.
Contraindications
•
individual hypersensitivity to active
substances and other components of the drug;
•
severe renal failure, progressive
kidney disease incl. confirmed hyperkalemia;
•
severe liver failure or active liver
disease;
•
decompensated heart failure;
•
erosive and ulcerative changes in the
mucous membrane of the stomach or duodenum, active gastrointestinal bleeding;
•
cerebrovascular bleeding or other
bleeding;
•
hypersensitivity to non-steroidal
anti-inflammatory drugs, acetylsalicylic acid;
•
pregnancy, breastfeeding period;
•
children and adolescents up to 18
years of age.
Method of
administration and dosage Inside during meals, preferably with
breakfast. 1 sachet 1 time per day.
Preparation: pour the contents of
the sachet into a glass (200 ml) of chilled boiled water, stir and drink.
Do not exceed the recommended dose unless directed by a doctor.
Special
instructions and precautions
Before using
the drug, consult a doctor!
Caution should be exercised when using
the drug in patients with a history of gastric ulcer and 12 duodenal ulcer, Crohn's disease, ulcerative
colitis, as well as in patients on anticoagulant therapy. These patients have
an increased risk of erosive and ulcerative lesions of the gastrointestinal
tract. Caution should be exercised and renal
function indicators should
be monitored when using
the drug in elderly patients, patients with chronic heart failure with symptoms
of circulatory failure, hypertension, in patients
with cirrhosis of the liver, as well
as in patients with hypovolemia as a result of surgical interventions.
The drug contains aspartame, so patients with phenylketonuria
should not take this drug.
Influence on the
ability to drive vehicles and mechanisms
During the period of treatment, care must be taken when driving
vehicles and engaging in other potentially hazardous activities that require an
increased concentration of attention and speed of psychomotor reactions.
Interaction
with other medicinal products
With the simultaneous use of glucosamine
•
with warfarin, the effect of warfarin
is enhanced, which can increase the risk of serious bruising and bleeding;
•
with anticancer drugs, the effect of
these drugs is reduced;
•
tetracycline, penicillin and
chloamphenicol, glucosamine enhances the absorption of tetracycline from the gastrointestinal tract
and reduces - penicillin
and chloramphenicol.
With the simultaneous use of meloxicam
•
with other non-steroidal
anti-inflammatory drugs (as well as with acetylsalicylic acid), the risk of erosive
and ulcerative lesions
and bleeding of the gastrointestinal tract increases;
•
with antihypertensive drugs, it is
possible to reduce the effectiveness of the latter;
•
with lithium preparations, it is
possible to develop lithium accumulation and increase its toxic effect (it is
recommended to control the concentration of lithium in the blood);
•
with methotrexate, the side effect of
the latter on the hematopoietic system increases (the risk of anemia and
leukopenia, periodic complete blood counts are indicated).
•
with diuretics and with cyclosporine,
the risk of developing renal failure increases.
•
with intrauterine contraceptives, it
is possible to reduce the effectiveness of the latter;
•
with anticoagulants (heparin,
ticlopidine, warfarin), as well as with thrombolytic drugs (streptokinase,
fibrinolysin), the risk of bleeding increases (periodic monitoring of blood
coagulation parameters is necessary);
•
with colestyramine, the excretion of
the drug from the body is accelerated;
•
With selective serotonin reuptake
inhibitors, the risk of developing gastrointestinal bleeding increases.
Side effect
•
nausea, vomiting, dyspepsia, heaviness
and pain in the abdomen, constipation, flatulence, diarrhea, belching,
esophagitis, gastroduodenal ulcer, hidden
or macroscopic gastrointestinal bleeding;
•
dizziness, drowsiness, headache;
•
erythema, itching;
•
rarely, transient changes in liver
function parameters. If any of the side
effects listed in the instructions get worse, or if you notice any other side
effects not listed in the instructions, tell your doctor.
Overdose
Symptoms: nausea, vomiting, epigastric pain, gastrointestinal
bleeding, impaired consciousness, acute renal failure, liver failure.
Treatment:
there is no specific antidote; in case of an overdose of the
drug, gastric lavage should be performed, activated charcoal
should be taken (within the next hour), symptomatic therapy.
Storage
conditions
Store in a dry and dark place, at a temperature not exceeding
25°C.
Keep out of the reach of children!
Shelf life
3 years. Do not use aſter the expiry date stated on the
packaging.
Vacation
conditions Dispensed by prescription.
Release form