TRIZOL [Metronidazole] 500 mg Solution for IV infusion
Brand name: Trizol
International non-proprietary name: Metronidazole
Dosage form: solution for infusion
Article: 6937861391555
Description
The product is a colorless or slightly yellowish transparent liquid.
COMPOSITION:
100 ml solution contains:
Active ingredient: Metronidazole 500 mg.
Excipients: Sodium chloride 900 mg, water for injection up to 100 ml.
PHARMACOTHERAPEUTIC GROUP
Antibacterial agent for systemic use.
PHARMACOLOGICAL PROPERTIES
Antiprotozoal agent. The exact mechanism of action of metronidazole is unknown. It is believed that the mechanism of action is associated with a violation of the DNA structure of sensitive microorganisms. Active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, as well as obligate anaerobic bacteria (including Bacteroides spp., Fusobacterium spp.). Aerobic microorganisms are resistant to metronidazole. Well absorbed after oral administration. Bioavailability is 80%. Distributed in tissues and body fluids. Penetrates through the blood-brain barrier. 60-80% of the drug is excreted in the urine.
INDICATIONS FOR USE
Extraintestinal amoebiasis, including amoebic liver abscess, intestinal amoebiasis (amebic dysentery), trichomoniasis, balantidiasis, giardiasis (giardiasis), cutaneous leishmaniasis, trichomonas vaginitis, trichomonas urethritis.
Infections of bones and joints, infections of the central nervous system, including meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis.
Infections of the abdominal cavity (peritonitis, liver abscess), infections of the pelvic organs (endometritis, abscess of the fallopian tubes and ovaries, infections of the vaginal fornix).
Gastritis or duodenal ulcer associated with Helicobacter pylori.
Prevention of postoperative complications (especially interventions on the colon, pararectal region, appendectomy, gynecological operations).
CONTRAINDICATIONS
Hypersensitivity to metronidazole or other nitroimidazole derivatives, organic lesions of the central nervous system, liver and / or kidney failure, I trimester of pregnancy, lactation (breastfeeding).
METHOD OF APPLICATION AND DOSES
The solution is administered intravenously, drip, at a rate of 5 ml per minute.
For adults and children over 12 years old, a single dose is 500 mg. The interval between injections is 8 hours. The duration of the course of treatment is determined individually. The maximum daily dose is not more than 4 g. According to indications, depending on the nature of the infection, a transition to maintenance therapy with oral forms of metronidazole is carried out.
Children under 12 years of age are administered 7.5 mg/kg of body weight (1.5 ml/kg) every 8 hours at a rate of 5 ml per minute.
For the prevention of anaerobic infections before a planned operation on the pelvic organs and urinary tract, adults and children over 12 years of age are prescribed the drug as an infusion at a dose of 500-1000 mg on the day of surgery, and the next day - at a dose of 1500 mg / day (500 mg each 8 hours). After 1-2 days, they usually switch to maintenance therapy with oral forms of metronidazole.
For patients with severe impaired renal and / or liver function, the daily dose of metronidazole is up to 1000 mg (2 doses).
SIDE EFFECTS
Nausea, vomiting, lack of appetite, unpleasant metallic taste, dry mouth (or vagina), diarrhea, headache, dizziness, impaired consciousness, sleep, irritability, depression, peripheral neuropathy, convulsions, tinnitus, hearing loss, allergic reactions (skin rashes, urticaria, itching), glossitis and stomatitis associated with the reproduction of fungi of the genus Candida, candidiasis.
SPECIAL INSTRUCTIONS
Use metronidazole with caution in liver diseases.
During the period of treatment with metronidazole, alcohol should be avoided, because. Acetaldehyde accumulation may occur due to impaired alcohol oxidation. As a result, reactions similar to those characteristic of disulfiram (spastic abdominal pain, nausea, vomiting, headache , sudden flushing of the face) may develop.
During the treatment of trichomonas vaginitis in women and trichomonas urethritis in men, it is recommended to refrain from sexual activity; simultaneous treatment of both partners is mandatory.
During the use of metronidazole, darker staining of urine is observed.
INTERACTIONS WITH OTHER DRUGS Metronidazole may enhance the effect of warfarin anticoagulants.
STORAGE CONDITIONS
Store in a dry place below 25°C. Keep away from the world.
Keep out of the reach of children!
BEST BEFORE DATE
3 years. Do not use after the expiry date stated on the package.
RELEASE FORM
Solution for infusion. A 100 ml PP bottle is placed in a cardboard box with instructions for use.
MANUFACTURER
The trademark and registration certificate are owned by Live Medicine Limited, UK.