LAVOR [Glutathione reduced] 600 mg Powder for solution for intramuscular injection, intravenous administration

LAVOR

instructions for medical use of the medicinal product

Tradename

Lavor, Lavor

International non-proprietary name

Glutathione, Glutathione

Compound

Each vial contains:

active ingredient: reduced glutathione 600 mg

The solvent ampoule contains: water for injection 5 ml

Dosage form

Lyophilized powder for solution for intravenous and intramuscular administration.

Pharmacotherapeutic group

Means used for poisoning and intoxication, hepatoprotector.

Pharmacological properties

Lavor is a tripeptide with a specific function, widely distributed in cells, which is involved in a number of biological processes and plays an important role in detoxification, protecting cells from the harmful effects of xenobiotics, free radicals and radiation. Glutathione contains glycine, cysteine and glutamic acid. Lavor is a strong hepatoprotector, antioxidant, immunomodulator and detoxifier.

Lavor has a beneficial effect on the immune and hematopoietic systems, allows you to cleanse the body of toxins, as well as protect liver cells from the influence of negative factors (toxins, alcohol, antibiotics). It has been established that at all stages of the immune response, free radicals and their derivatives, as well as the antioxidant system, perform a regulatory function and can help limit or activate immune responses. Lavor is one of the main links in the regulation of the immune response.

Glutathione injections are usually used as part of the complex therapy of a number of diseases and for preventive purposes.

Lavor is found in large quantities in the liver, erythrocytes and adrenal glands. The reduced form of glutathione activates some enzyme systems.

Glutathione binds to heavy metal ions, which act on sulfhydryl and disulfide groups of proteins, renders them harmless. Lavor is involved in metabolism as a carrier of hydrogen. It is the most powerful biological antioxidant in the human body, but premature infants have a deficiency of reduced glutathione, which increases with an increase in the degree of prematurity. After birth, reduced glutathione deficiency is a compensatory defense mechanism for the lungs against the damaging effects of oxidative stress.

Erythrocytes containing a small amount of reduced glutathione are relatively easily destroyed.

Lavor is necessary for the metabolism of carbohydrates, has an effect on lipid metabolism, prevents the development of atherosclerosis, and slows down aging. Specific correlation changes in the components of the glutathione system in patients with diabetes mellitus, aimed at the reduction of peroxide compounds and the neutralization of free radicals, were revealed.

Glutathione deficiency, affecting the nervous system, leads to disturbances in the processes of thinking, coordination and is the cause of tremor.

It should be noted that with gestational complications in pregnant women, significant changes in the placental glutathione system are revealed, which should be considered as compensatory-adaptive reactions that prevent the progression of both preeclampsia and chronic placental insufficiency.

Clinical studies have confirmed that glutathione infusion, prior to the introduction of anticancer chemotherapy in patients with ovarian carcinoma, gastric carcinoma, and

colorectal cancer, provides effective protection against renal failure and neurotoxicity caused by the use of cisplatin and oxaliplatin, which allows, if necessary, to achieve higher cumulative doses of the anticancer agent.

15 minutes after an intravenous infusion of 2 g of glutathione, the average concentration of glutathione in the blood is 444 mmol/l (the average physiological concentration of glutathione in the blood is 6.9 mmol/l). Distribution volume - 15 l. The half-life is 10 minutes. Clearance - 850 ml / min. It is excreted in the urine unchanged or as cysteine 90 minutes after infusion.

Indications for use

Liver damage toxic, including alcoholic, viral - hepatitis A, B, C, medicinal (antibiotics, antitumor, antitubercular, anticonvulsant, antiviral drugs, NSAIDs, antidepressants, oral contraceptives). Liver cirrhosis, hepatic steatosis, liver fibrosis, precirrhotic conditions. Intrahepatic cholestasis. Postoperative period (to eliminate the residual effects of anesthesia) Encephalopathy, incl. associated with liver failure (alcohol, etc.) Depressive and withdrawal syndrome. Parkinsonism, Alzheimer's disease. Neuropathic, nephrotoxic, hepatotoxic prophylaxis, during chemotherapy treatment with cyclophosphamide, doxorubicin, bleomycin, chicken or its analogue. Diabetes mellitus, thyrotoxicosis, atherosclerosis, arthritis, gout. Poisoning of various etiologies (alcohol, drugs, heavy metals, etc.). In complex therapy for chronic and acute lung diseases - COPD, chronic bronchitis, pneumonia, tuberculosis. Skin diseases - psoriasis, vitiligo, atopic dermatitis. Renal failure, nephropathy. Infertility, oligospermia.

Contraindications

Hypersensitivity to the active substance or other components of the drug. Childhood.

Dosage and administration

Intramuscularly, intravenously.

For intramuscular injection, dissolve the powder in a vial in water for injection and inject intramuscularly.

For intravenous injection, dissolve the powder in a vial in water for injection and inject intravenously (slowly over 2-3 minutes) or add saline for intravenous drip.

Oncology: in order to protect against ionizing effects during radio and radiation therapy, 600-1200 mg is administered intravenously in 50-200 ml of saline 15 minutes before radio and radiation therapy. In order to protect neurons, heart cells, nephrons from the toxicity of chemotherapy (cisplatin, oxaliplatin, etc.) is prescribed at a dosage of 1200 mg intravenously in saline 50-200 ml 15 minutes before the use of chemotherapy.

For other indications: in mild forms, the drug is administered intramuscularly, intravenously slowly or by infusion in saline 50-200 ml, 600 mg per day, for 10-20 days.

In severe forms, the drug is administered intramuscularly, intravenously slowly or by infusion in saline 50-200 ml, 1200 mg per day, for 10-20 days.

For appropriate explanations about the use of the drug, patients are advised to consult a doctor or pharmacist.

Special instructions and precautions

The drug must be thoroughly dissolved in a solvent ampoule.

The resulting solution should be clear and colorless.

If symptoms of allergy appear, it is necessary to stop using the drug.

Influence on the ability to drive vehicles and mechanisms

In view of the possible manifestations of side effects of the drug, the drug should be used with caution in persons driving vehicles and servicing mechanisms.

Use during pregnancy and during breastfeeding

Use during pregnancy and lactation is contraindicated. If necessary, the use of the drug during lactation should stop breastfeeding.

Interaction with other drugs

There were no cases of incompatibility of Lavor with other drugs.

Side effect

In rare cases, nausea, vomiting, headache, and skin rashes are possible. These reactions usually disappear after cessation of therapy.

If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

There were no cases of overdose. In the event of an overdose, symptomatic therapy should be used.

Storage conditions

In a dry, dark place at a temperature not exceeding 25°C.

Keep out of the reach of children!

Best before date

3 years. Do not use after the expiry date stated on the packaging.

Holiday conditions

Released by prescription.

Release form

5 bottles with powder for solution preparation, 5 ampoules with a solvent of 5 ml, together with instructions for use in a cardboard box.