Tradename

Bonical, Bonical

International non-proprietary name

Calcium Carbonate + Vitamin D 3, Calcium Carbonate + Vitamin D3 _

Compound

Each effervescent tablet contains:

active substance:

Carbonate calcium BP 625 mg (in form Calcium 250 mg), Colecalciferol BP (vitamin D 3) 200 IU

excipients : Q. S. _ Color: Sunset Yellow

Dosage form

Effervescent tablets.

Pharmacological properties

Bonical effervescent tablets contain calcium and colecalciferol (vit. D 3). Bonical tablets are used to prevent and treat calcium and vitamin D deficiencies , as well as with other medicines for prevention and treatment osteoporosis.

Calcium and vitamin D 3 are absorbed from the intestines and distributed throughout organism with blood. 99% of calcium in the human body is in the bones in the form crystals.

Hydroxyapatite and amorphous phosphate calcium. These compounds are important for maintaining strong bones and teeth. Calcium plays an important role in several functions organism . It is essential for the functioning of nerves, muscles, and the heart, as well as for blood clotting. In addition, it helps many hormones work properly in the body. To perform these various functions, calcium must be available at the appropriate concentration. Vitamin D 3 helps calcium absorption and phosphorus from the intestines and their absorption by the bones. Vitamin D can be found in certain foods or supplements such as fish oil, oily fish, eggs, and is also produced by the skin. in presence of sunlight. However, vitamin deficiency D all more maybe arise in dependencies from Togo, where human lives (latitude), time spent outdoors, and diet.

Indications for use

BONICAL effervescent tablets are indicated as a daily dietary supplement for conditions requiring calcium supplementation. Clinical conditions associated with calcium deficiency and vitamin D , such how pregnancy, lactation, a as well as prevention and treatment osteoporosis.

Contraindications

BONICAL is contraindicated in patients with hypersensitivity to any component of the drug. It is contraindicated in patients with hypercalcemia and hypercalciuria (for example, hyperparathyroidism, vitamin D overdose , decalcifying tumors such as plasmacytoma, bone metastases ) severe kidney disease; loss of calcium due to immobilization.

Special instructions and measures precautions. With moderate hypercalcemia (more than 300 mg/24 h), as well as in chronic renal failure or at availability signs of formation of stones in the urinary tract, it is necessary to carry out adequate control of calcium excretion with urine. If necessary, the dose should be reduced or stop calcium therapy. Patients prone to stone formation   in the urinary tract, recommended increased fluid intake.

Use during pregnancy and during breastfeeding

During pregnancy and lactation breast treatment should always be carried out under the guidance of a physician. During pregnancy and lactation, the need for calcium and vitamin D increases, but the availability of these substances from other sources should be taken into account when deciding on the necessary supplements.

Interaction with other drugs

Calcium absorption from the gastrointestinal tract may be reduced by concomitant intake of foods rich in oxalic acid and phytic acid, eg. bran, rhubarb and spinach. The patient should not take effervescent tablets BONICAL within 2 hours after the use of such products.

Simultaneous use corticosteroids may reduce calcium absorption. Due to the possible formation of non-absorbable complexes. BONICAL effervescent tablet may reduce the absorption of estramustine, quinolones, phenytoin, tetracyclines and sodium fluoride. These substances should be taken at least 2 hours before taking BONICAL effervescent tablets or after 6 hours after him. BONICAL effervescent tablets also reduce the absorption of bisphosphonates.

Administration of large doses of oral calcium may increase the risk of cardiac arrhythmias in patients taking digitalis. Reabsorption of calcium in the kidneys aggravated by thiazide diuretics, leading to hypercalcemia.

Due to the possible formation of non-absorbable complexes, BONICAL effervescent tablets may reduce the absorption of other medicinal products not listed above.

Side effect

Sometimes diarrhea or constipation can occur with high calcium intake.

Overdose

???

Storage conditions

Store in a cool (below 25° C ), dry place. Keep away from moisture and light.

Keep out of the reach of children!

Best before date

3 years. Do not use after the expiry date stated on the package.

Holiday conditions

Released by prescription.

Release form

20 tablets in a tube. BONICAL is packaged in a cardboard box along with a leaflet.