LABOCOF

Instructions for use of the medicinal product

Trade name of the drug : Labocof.

Active ingredient (INN) : Polycomponent agent.

Dosage form : tablets.

Compound

One tablet contains:

active substances : guaifenesin BP 50 mg

bromhexine hydrochloride BP 4 mg

chlorphenamine maleate BP 4 mg

phenylephrine hydrochloride BP 5 mg

paracetamol BP 450 mg

excipients: fillers qs

Pharmacological properties

Combined drug with expectorant, mucolytic, antipyretic, decongestant and antihistamine action.

Pharmacodynamics

Guaifenesin - reduces the adhesive properties of sputum, increases the serous component of bronchial secretions, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and promotes the transition from an unproductive cough to a productive one.

Bromhexine hydrochloride is a mucolytic agent that has an expectorant and slightly antitussive effect. Reduces the viscosity of sputum due to the depolarization of acid mucopolysaccharides and stimulation of the secretory cells of the bronchial mucosa. It activates the cilia of the ciliated epithelium, as a result of which sputum discharge improves.

Chlorphenamine maleate is an antihistamine, a blocker of H1 histamine receptors. Reduces the severity of allergic reactions, capillary permeability, constricts blood vessels.

Phenylephrine hydrochloride is an adrenergic mimetic that has a direct stimulating effect mainly on α-blockers. It is used as a stimulant, decongestant and anorexigenic agent.

Paracetamol is an antipyretic that reduces fever by affecting the part of the brain known as the hypothalamus, which regulates body temperature associated with colds and flu.

Pharmacokinetics

Guaifenesin is rapidly absorbed from the gastrointestinal tract (25-30 minutes after ingestion). Penetrates into tissues containing mucopolysaccharides. Metabolized in the liver T _½ - 1 hour Excreted with sputum through the lungs and kidneys in the form of inactive metabolites.

Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and is extensively metabolized during the first pass through the liver. Widely distributed in body tissues. About 85-90% is excreted in the urine mainly in the form of metabolites.

Chlorphenamine maleate after oral administration is relatively slowly absorbed from the gastrointestinal tract. Cmax is reached in 2.5-6 hours. Bioavailability is low - 25-50%. Binding to blood proteins 70%. T _½ from 2 to 43 hours.

Phenylephrine hydrochloride after oral administration is poorly absorbed from the gastrointestinal tract. It is metabolized with the participation of MAO in the intestinal wall and during the “first pass” through the liver. The bioavailability of phenylephrine is low.

Paracetamol is rapidly absorbed from the gastrointestinal tract, approximately within 30 minutes to 2 hours after a meal. It is metabolized in the liver. Less than 5% is excreted as unchanged paracetamol. The elimination half-life varies from about 1 to 4 hours.

Indications for use

Elimination of cold and flu symptoms such as fever, headache, chills. Acute and chronic diseases of the bronchi and lungs, accompanied by difficulty in sputum discharge, bronchial asthma, chronic bronchitis, chronic obstructive pulmonary disease, tracheobronchitis, pneumonia.

Contraindications

Hypersensitivity to the components that make up the drug, myocarditis, aortic stenosis, decompensated diabetes mellitus, liver and kidney failure.

Dosage and administration

How to use: inside, after meals with water.

Dosage regimen: for adults and children over 12 years old, 1-2 tab. 3-4 times a day.

Children aged 6 to 12 years, ½ tab. 3-4 times a day.

Children under the age of 6 years - ¼-½ tab. 3-4 times a day.

The course of treatment is determined by the attending physician.

Do not exceed the prescribed dose.

Side effects

From the side of the central nervous system: headache, dizziness, sleep disturbance, drowsiness, tremor, convulsions.

From the gastrointestinal tract: dry mouth, nausea, vomiting, diarrhea, exacerbation of gastric and duodenal ulcers, increased activity of "liver" transaminases (extremely rare).

From the CCC: tachycardia, lowering blood pressure, collapse.

special instructions

Take with caution in diabetes mellitus, arterial hypertension, peptic ulcer of the stomach and duodenum (in history), during pregnancy and lactation (only in cases where the potential benefit of the mother outweighs the expected risk of the fetus and child), children under 3 years.

Guaifenesin turns urine pink.

It is not recommended to drink the drug with alkaline drink.

When taking the drug, it is desirable to refrain from driving vehicles and other mechanisms.

Overdose

Symptoms: may increase the manifestations described in side effects.

Treatment: symptomatic therapy.

Interaction with drugs

β2-agonists, theophylline and other xanthines, when used simultaneously with drugs, increase the likelihood of developing tachyarrhythmias.

Simultaneous administration with preparations containing codeine and other antitussives makes it difficult to expel liquefied sputum.

The hydrochloride contained in bromhexine promotes the penetration of antibiotics into the lung tissue.

It is not recommended to take simultaneously with non-selective β-adrenergic blockers, monoamine oxidase inhibitors (MAO) and antitussives.

Storage conditions

Store in a cool, dry and dark place.

Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date.

Release form

10 tablets / strip, 25 strips / instructions for use / packaging.

Terms of dispensing from pharmacies

Without recipe.